研究生教学

-基本信息

-研究方向

绿色有机合成与医学应用；有机合成方法学。

-教育经历

2010/10–2014/2 德国哥廷根大学化学学院，有机化学，博士，导师：Lutz Ackermann 教授

2007/9–2010/7 郑州大学化学系，有机化学，硕士，导师：朱志兀教授

2003/9–2007/7 郑州大学化学系，化学，学士

-科研与学术工作经历

2014/7– 87978797威尼斯老品牌生物医学学院讲师、副教授，硕士生导师

-主讲课程

【本科生】《有机化学》，《有机化学实验》，《医用化学（有机部分）》，《化学史话》（校通识课）；【研究生】《功能有机分子的设计与合成》，《高等有机化学》。

-主持科研项目

1. 烯基叠氮参与的氮杂环医药分子骨架构筑（2018C073R），泉州市科技计划项目，20 万。

2. 福建省高校杰出青年科研人才培育计划，4 万。

3. 膦-磷叶立德双齿配体介导的 C–H 键官能团化反应研究（21602064），国家自然科学基金青年项目，20 万。

4. 基于过渡金属催化 C–H 键活化的氧化偶联反应研究（2015J01056），福建省自然科学基金面上项目，4 万。

5. 可移去/修饰导向基作用下的 C–H 键功能化反应研究（JA15032），福建省中青年教师教育科研项目，2 万。

6. 易修饰导向基作用下的直接 C–H 键活化反应研究（ZQN-PY317），中央高校基本科研业务费，40 万。

7. 基于金属催化直接 C–H 键功能团化反应研究（16BS106），87978797威尼斯老品牌科研启动基金，6 万。

-入选人才计划项目

1. 福建省高校杰出青年科研人才培育计划（2018）

2. 泉州市“海纳百川”高端人才聚集计划（2015）

-主要发表文章

27. H. Wang, H. Huang, C. Gong, Y. Diao, J. Chen, S.-H. Wu*, L. Wang*, Nickel-catalyzed chemo- and regioselective benzylarylation of unactivited alkenes with o-bromobenzyl chlorides. Org. Lett., 2022, 24, 328−333.

26. H. Huang, H. Wang, C. Gong, Z. Zhuang, W. Feng, S.-H. Wu*, L. Wang*, Synthesis of 2-trifluoromethylquinolines through rhodium-catalysed redox-neutral [3+3] annulation between anilines and CF₃-ynones using traceless directing group. Org. Chem. Front., 2022, 9, 413−419.

25. M. Yang, J. Wang, W. Lv, D. Ba, G. Cheng*, L. Wang*, Synthesis of 2-alkenyl-4H-3,1-benzoxazin-4-ones through HFIP-mediated decarboxylative [4+2]-annulation of isatoic anhydrides with cyclopropenones under silver catalysis. Adv. Synth. Catal., 2021, 363, 4085−4090.

24. J. Wang, D. Ba, M. Yang, G. Cheng*, L. Wang*, Regioselective synthesis of 2,4-diaryl-6-trifluoromethylated pyridines through copper-catalyzed cyclization of CF₃-ynones and vinyl azides. J. Org. Chem., 2021, 86, 6423−6432.

23. Z. Shi, L. Wang*, Z. Yang, L. Jie, X. Liu, X. Cui*, Tandem construction of indole-fused phthalazines from (2-alkynylbenzylidene)hydrazines under metal-free conditions. J. Org. Chem., 2020, 85, 3029−3040.

22. W. Fu, L. Wang*, Z. Yang, J.-S. Shen, F. Tang, J. Zhang, X. Cui*, Facile access to versatile aza-macrolides through iridium-catalysed cascade allyl-amination/macrolactonization. Chem. Commun., 2020, 56, 960−963.

21. Z. Shi, L. Wang*, X. Cui*, Recent advances in the I₂-catalyzed C−H bond functionalizations. Chin. J. Org. Chem., 2019, 39, 1596−1612.

20. L. Jie, L. Wang*, D. Xiong, Z. Yang, D. Zhao, X. Cui*, Synthesis of 2‑arylindoles through Pd(II)-catalyzed cyclization of anilines with vinyl azides. J. Org. Chem., 2018, 83, 10974−10984.

19. D. Xiong, L. Wang*, L. Jie, Z. Yang, L. Li, X. Cui*, Rhodium-catalyzed mild C7-amination of indolines with nitrosobenzenes. ChemistrySelect, 2018, 3, 13497–13500.

18. L. Wang, D. Xiong, L. Jie, C. Yu, X. Cui*, Rhodium-catalyzed oxidative homologation of N-pyrimidyl indolines with alkynes via dual C–H activation: facile synthesis of benzo[g]indolines, Chin. Chem. Lett., 2018, 29, 907–910.

17. L. Wang, Y. Yu, M. Yang, C. Kuai, D. Cai, J. Yu, X. Cui*, Rhodium-catalyzed synthesis of multiaryl-substituted naphthols via a removable directing group. Adv. Synth. Catal., 2017, 359, 3818−3825.

16. L. Wang, Z. Yang, M. Yang, M. Tian, C. Kuai, X. Cui*, Facile route to ortho-hydroxyanilnes through an Ir^III-catalyzed direct C–H amidation of 2-phenoxypyridines. Chem. Asian J., 2017, 12, 2634–2643.

15. L. Wang, Z. Yang, M. Yang, R. Zhang, C. Kuai, X. Cui*, Iridium-catalyzed direct C–H amidation of anilines with sulfonyl azides: easy access to 1,2-diaminobenzenes. Org. Biomol. Chem., 2017, 15, 8302−8307.

14. L. Xu, L. Wang, Y. Feng, Y. Li, L. Yang, X. Cui*, Iridium(III)-catalyzed one-pot access to 1,2-disubstituted benzimidazoles starting from imidamides and sulfonyl azides. Org. Lett., 2017, 19, 4343−4346.

13. C. Kuai, L. Wang, B. Li, Z. Yang, X. Cui*, Cobalt-catalyzed selective synthesis of isoquinolines using picolinamide as a traceless directing group. Org. Lett., 2017, 19, 2102−2105.

12. C. Kuai, L. Wang, H. Cui, J. Shen, Y. Feng, X. Cui*, Efficient and selective synthesis of (E)-enamides via Ru(II)-catalyzed hydromidation of internal alkynes. ACS Catal., 2016, 6, 186–190.

11. M. Wei, L. Wang, Y. Li, X. Cui*, Iridium-catalyzed direct ortho-C–H amidation of benzoic acids with sulfonylazides. Chin. Chem. Lett., 2015, 26, 1336–1340.

10. J. Mo, L. Wang, X. Cui*, Rhodium(III)-catalyzed C–H activation/alkyne annulation by weak coordination of peresters with O–O bond as an internal oxidant. Org. Lett., 2015, 17, 4960–4963.

9. J. Mo, L. Wang, Y. Liu, X. Cui*, Transition-metal-catalyzed direct C–H functionalization under external-oxidant-free conditions. Synthesis, 2015, 47, 439–459. (Invited review)

8. L. Wang, K. Rauch, A. V. Lygin, S. I. Kozhushkov, L. Ackermann*, Ruthenium-catalyzed direct oxidative alkenylation of arenes through twofold C–H bond functionalization in water: synthesis of ethyl (E)-3-(2-acetamido-4-methylphenyl)acrylate. Org. Synth., 2015, 92, 131–147.

7. M. Schinkel, L. Wang, K. Bielefeld, L. Ackermann*, Ruthenium(II)-catalyzed C(sp(3))–H alpha-alkylation of pyrrolidines. Org. Lett., 2014, 16, 1876–1879.

6. L. Wang, L. Ackermann*, Ruthenium-catalyzed ortho-C–H halogenations of benzamides. Chem. Commun., 2014, 50, 1083–1085.

5. L. Wang, L. Ackermann*, Versatile pyrrole synthesis through ruthenium(II)-catalyzed alkene C–H bond functionalization on enamines. Org. Lett., 2013, 15, 176–179.

4. L. Ackermann*, L. Wang, A. V. Lygin, Ruthenium-catalyzed aerobic oxidative coupling of alkynes with 2-aryl-substituted pyrroles. Chem. Sci., 2012, 3, 177–180.

3. L. Ackermann*, L. Wang, R. Wolfram, A. V. Lygin, Ruthenium-catalyzed oxidative C–H alkenylations of anilides and benzamides in water. Org. Lett., 2012, 14, 728–731.

2. L. Wang, X. Cui*, J. Li, Y. Wu, Z. Zhu, Y. Wu*, Synthesis of biaryls through a one-pot tandem borylation/Suzuki-Miyaura cross-coupling reaction catalyzed by a palladacycle. Eur. J. Org. Chem., 2012, 595–603.

1. L. Wang, J. Li, X. Cui*, Y. Wu, Z. Zhu, Y. Wu*, Cyclopalladated ferrocenylimine as efficient catalyst for the syntheses of arylboronate esters. Adv. Synth. Catal., 2010, 352, 2002–2010.

-授权发明专利

2. 王连会，施兆江，崔秀灵，一种吲哚并[2,1-a]酞嗪衍生物的制备方法，2019.2.1，中国，ZL201910106178.7。

1. 王连会，崔秀灵，揭亮华， 一种N-（2-吡啶/嘧啶基）吲哚衍生物的制备方法，2018.1.8，中国，ZL201810017134.2。